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KMID : 1084220150220030167
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Journal of Rheumatic Diseases
2015 Volume.22 No. 3 p.167 ~ p.174
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Extraglandular Manifestations in Korean Patients with Primary Sjogren′s Syndrome
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Choi Byoong-Yong
Yoo Jong-Jin
Oh Hye-Jin
Jang Yu-Jin
Lee Yun-Jong
Song Yeong-Wook
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Abstract
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Objectives: To investigate the clinical findings upon initial diagnosis and extraglandular manifestations in Korean patients with primary Sjogren’s syndrome (pSS).
Methods: We collected clinical and laboratory data from 238 pSS patients enrolled at Seoul National University Hospital, Seoul National University Bundang Hospital and Seoul Medical Center from March 2011 to December 2014. All patients met the American-European Consensus Group criteria for pSS.
Results: Upon initial diagnosis, sic-ca symptoms (xerophthalmia or xerostomia) as the chief complaint were only observed in 129 (54.2%) pSS patients, while ex-traglandular manifestation was more common as the chief complaint in male patients or those with younger age (＜40 years) than female or older patients (both p＜0.05). Extraglandular manifestations were found in 178 (74.8%) patients, with muscu-loskeletal manifestations being most common (53.8%). Peripheral neuropathy in pSS patients was associated with Raynaud phenomenon and elevated serum total immunoglobulin G (IgG) levels (both p＜0.05). Serum β2-microglobulin (β2-M) levels were significantly correlated with European League against Rheumatism (EULAR) Sjogren’s syndrome disease activity index, erythrocyte sedimentation rate and serum total IgG (all p＜0.001), and were higher in patients with extraglandular manifes-tations than those without (p＜0.05). Serum C3 levels were decreased in patients with extraglandular manifestation, compared to those without (p＜0.05). Malignant lymphoma was found in Korean pSS patients (1.7%) and associated with elevated serum β2-M levels (p＜0.0001).
Conclusion: Extraglandular manifestations were common in pSS patients and may be a diagnostic tool for male or younger pSS patients. Serum β2-M levels can be useful markers for monitoring pSS patients.
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KEYWORD
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Sjogren’s syndrome, Extraglandular manifestation, Beta 2-microglobulin, Lymphoma
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